GlueHunter1.0 integrates two specialized engines that accelerate the discovery Neo-degradable targets and molecular glues/PPI modulators through complementary pattern recognition analysis

1. 1Neo-substrate Identification

   Analyzes surface interactions, target recruitment and anchoring factors, and structural complementarity to identify novel neo-substrates with high therapeutic potential.

2. 2Molecular Glue Discovery

   Extracts geometric and topological features, maps 3D conformational changes, and profiles dynamic binding interfaces to enable the rational design of tailored molecular glues.

Applications
Enables the end-to-end discovery of molecular glue degraders and stabilizers, the identification of novel neo-substrates, and the design of PPI modulators to precisely regulate protein–protein interactions, driving therapeutic innovation across oncology, neurodegeneration, and other disease areas.

LeadHunter 2.0 analyzes therapeutically actionable patterns through atomic-level assessment of three-dimensional structural data, powered by the dynamic conformational changes of target proteins.
This approach goes beyond static models to reveal hidden opportunities for drug intervention.

1. 1Hot Spot Identification

   Evaluates binding affinity, functional and disease-associated mechanisms, and structural complementarity to pinpoint functionally relevant binding sites with high druggability.

2. 2Motion & Motility Analysis

   Profiles geometric and topological features, captures 3D conformational changes, and maps dynamic binding interfaces to uncover previously inaccessible regulatory sites.

Applications
Enables the discovery of small molecule regulators—including inhibitors and activators—designed to precisely modulate target protein function.